Basic Information
VIS ID
TVIS30001044
Fusion event
HIV-ARHGEF6 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
135753225/136671066 (Hg38)
End
135754050/136671066 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGEF6
miRNAs that regulate target gene
hsa-mir-30c-5p ; hsa-mir-877-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4306 ; hsa-mir-4644 ; hsa-mir-185-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-1253 ; hsa-mir-6760-5p ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-5197-3p ; hsa-mir-888-5p ; hsa-mir-371a-5p
Nearest miRNA
hsa-let-7f-2/Upstream/120106; hsa-mir-105-1/Downstream/1996645;
Nearest TSS
ENST00000429181/Upstream/22839; ENST00000478471/Downstream/96277;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/173126, chrX-CpG: 104/Downstream/95805
Target sequence
GTTATAATAAGAATTAACTAACATTATTTATTGAGCTAGCCTTTATACTTATTTCACTTAACCTCACAACAACTCTGAAAGCATTACCGTCATCCTTATTTTACAGATGAGGAAACTGAGGCACAGAGAGGTGAAGCAACTTGCCCCAGGTCACACAGCTAATGAGTAGCAGAAGTGGGAGTTGAACCACACTGTTTTTTGCTTGAGCCCAAGTACTTAACCATTTTGCTGTATCACTTCACACATCAGATGTAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate