VISDB - VIS Detail

Basic Information

VIS ID

TVIS30001045

Fusion event

HIV-BICDL1 integration

Validated

Yes

Detection method

QiaQuick PCR and Sequencing

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

25011556

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr12

Cytoband

q24.23

Reference genome

GRCh37/hg19

Start

120481952/120044148 (Hg38)

End

120482773/120044148 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA12E ; FRA12C

Target gene

BICDL1

miRNAs that regulate target gene

hsa-mir-4260 ; hsa-mir-1227-5p ; hsa-mir-3678-3p ; hsa-mir-7847-3p ; hsa-mir-6880-5p ; hsa-mir-4483 ; hsa-mir-1293 ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-6745 ; hsa-mir-363-5p ; hsa-mir-6816-5p ; hsa-mir-3196 ; hsa-mir-3180-3p ; hsa-mir-3180 ; hsa-mir-128-2-5p ; hsa-mir-128-1-5p ; hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-2861 ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-661 ; hsa-mir-2467-3p ; hsa-mir-423-5p ; hsa-mir-6776-5p ; hsa-mir-3184-5p ; hsa-mir-3158-5p ; hsa-mir-6742-3p ; hsa-mir-4779 ; hsa-mir-1249-5p ; hsa-mir-1273a ; hsa-mir-1273h-5p ; hsa-mir-149-3p ; hsa-mir-2278 ; hsa-mir-30b-3p ; hsa-mir-3192-5p ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-4419a ; hsa-mir-4510 ; hsa-mir-4519 ; hsa-mir-4716-3p ; hsa-mir-4728-5p ; hsa-mir-5693 ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6731-5p ; hsa-mir-6760-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6785-5p ; hsa-mir-6794-5p ; hsa-mir-6797-5p ; hsa-mir-6798-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-7106-5p ; hsa-mir-8085

Nearest miRNA

hsa-let-7i/Upstream/330424; hsa-mir-3612/Downstream/111286;

Nearest TSS

ENST00000382841/Upstream/44295; ENST00000546790/Downstream/20489;

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/53886, chr12-CpG: 36/Downstream/42734

Target sequence

ATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAAAAGAGCCCGCATCGCCAAGTCAATCCTACGCCAAAAGAACAAAGCCGGAGGCATCACACTACCTGACTTCAAACTATACTACAAGGCTACAGTAACCAAAACAGCATGGTACTGGTACCAAAACAGAGATATAGATCAATGGAACAGAACAGAGCCCTCAGAAATAACGCCGCATATCTAC

Reference

Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.