Basic Information
VIS ID
TVIS30001048
Fusion event
HIV-HTT integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
3124952/3123225 (Hg38)
End
3125173/3123225 (Hg38)
Orient
+
Location type
Intronic
Target gene
HTT
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-421 ; hsa-mir-324-5p ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-16-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-4800/Upstream/873069; hsa-mir-12113/Downstream/2800050;
Nearest TSS
ENST00000502981/Upstream/1825; ENST00000509618/Downstream/5114;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/48394, chr4-CpG: 73/Downstream/125675
Target sequence
ACAGAGTGTAAACATCTTAGCTTTATGGGCCATATGGTCTCTTTTGCAACATTCAGCTCTGCCCTGTGACAGGAATGCAGTTGTAAAGACATGAGCTACTGGCCAGCTATGTTCCAGTAGAACTTTACTTACAGAAACAGACAGGCTGTAGTTTGCCAATACCTGCCTTAGGGAATGTGTTGTTATATTTTGTGAGTTACCTTCTCAGTAAATTTTATTTA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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