Basic Information
VIS ID
TVIS30001049
Fusion event
HIV-KIF18A integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
28114507/28092960 (Hg38)
End
28115380/28092960 (Hg38)
Orient
+
Location type
Intronic
Target gene
KIF18A
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-210/Upstream/36050; hsa-let-7a-2/Downstream/384521;
Nearest TSS
ENST00000527297/Upstream/4380; ENST00000403099/Downstream/4927;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/369943, chr11-CpG: 25/Downstream/17356
Target sequence
CCAAGGAGCATTTAAAAAACACAGATGCCTCAGCCACACCCCAGACCTACTAAATTAAAATATCCCAAGTGTGAGGCCTAGGCCTATTTTTAAAAAGTTCTATAGGCAATTCTGGTGCACAGCTTGAGTAGAAAACCATATTATACACTGCCTTATCATTAATAATATGAAAGTAGATTAAAAGAAAAAATAAAAATTGTGAAAATAACCAAACTTCAAAATTCTCCCAGTTATAAAAAGGATCTAAGGAAAAAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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