Basic Information
VIS ID
TVIS30001051
Fusion event
HIV-MGA integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.1
Reference genome
GRCh37/hg19
Start
41978804/41686606 (Hg38)
End
41979238/41686606 (Hg38)
Orient
+
Location type
Intronic
Target gene
MGA
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p
Nearest miRNA
hsa-mir-1233-1/Upstream/4713705; hsa-mir-10393/Downstream/4979;
Nearest TSS
ENST00000557528/Upstream/16882; ENST00000566288/Downstream/47948;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/24466, chr15-CpG: 63/Downstream/87684
Target sequence
TTGGGTGTAGTTTTTGTGTAGTGCTTTTTATCATGTTGAAATACTTTCCTACTGTTACCCATTTTCCTGAATATTGTTAAGAATGAGTGTTGAATTTCATCAAATGATTTTTCTAAATCCATTGAAATACCATATGTTTTTTCTCCTTTATTTTGTTAATATGGTGAATTAACATTGATTTAGAGGGGAGGGGTGATCTTACATTCTTGGGCTAAACATTACCTGGCCATGATGATATCATCCTTTTTAATATTA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate