Basic Information
VIS ID
TVIS30001054
Fusion event
HIV-PLCB1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
8222443/8241796 (Hg38)
End
8223321/8241796 (Hg38)
Orient
-
Location type
Intronic
Target gene
PLCB1
miRNAs that regulate target gene
hsa-mir-423-5p ; hsa-mir-30c-5p ; hsa-mir-297 ; hsa-mir-4325 ; hsa-mir-6867-5p ; hsa-mir-567 ; hsa-mir-223-5p ; hsa-mir-3607-5p ; hsa-mir-511-3p ; hsa-mir-502-3p ; hsa-mir-501-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/870104; hsa-mir-1-1/Downstream/2407840;
Nearest TSS
ENST00000382410/Upstream/91471; ENST00000636784/Downstream/63878;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/108851, chr20-CpG: 107/Downstream/826515
Target sequence
GTATTGCCATTCCTCTCTTTTCTCTCTAAGTCGACTAATGTATCCCTAGGCCTCTATTGTTACCACTACCTTTCAGCTCACCTCTGGCGCTCAGCCTCTCCACCCTTTCAACTTGCCATATATCAAACACCTTTCCCTTGCAAACTTCCCCTCTCAATTAGAGGATCAAGTGCCTGGTTTTGCAGTGGCCTTTAAGTACTCCTTAGTAAGTCTGACCACATTGACCCCTCACTTCTCCTGTTCCTTGTGGTTCAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate