Basic Information
VIS ID
TVIS30001055
Fusion event
HIV-RANBP3 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
5920719/5920708 (Hg38)
End
5921533/5920708 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
RANBP3
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-455-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1227/Upstream/987968; hsa-let-7e/Downstream/468930;
Nearest TSS
ENST00000633603/Upstream/6435; ENST00000587836/Downstream/3166;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/5418, chr19-CpG: 145/Downstream/56721
Target sequence
ATTCTTTTAATTTCAGATACCCCTTATACAATGTAAAGCCTGTTCTAGCTTGAGGGCAGGACAAAAAACTGACCAAGGTGGCCCCCAGGCCGTCGTTGGCTGGCCCTGGCAGTCCCCACAGGCTAAAGGGCGACTCTCAGGGTGTGGCTGCAGCAGGACACCAGCTGGGGTCCCTGCTTACCGGCGGCCACTGTGTTCCAGATGCAGTGCAAGCTGTTTGTCTTTGACAAGACCTCACAGTCCTGGGTGGAGAGA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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