Basic Information
VIS ID
TVIS30001056
Fusion event
HIV-REV3L integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
111799921/111478718 (Hg38)
End
111800379/111478718 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6F
Target gene
REV3L
miRNAs that regulate target gene
hsa-mir-340-5p ; hsa-mir-183-5p ; hsa-mir-93-5p ; hsa-mir-21-5p ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-4282 ; hsa-mir-218-5p ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-124-5p ; hsa-mir-4470 ; hsa-mir-6505-5p ; hsa-mir-4694-3p ; hsa-mir-3163 ; hsa-mir-8054 ; hsa-mir-548l ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-92b-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-10398/Upstream/4694498; hsa-mir-1202/Downstream/7590329;
Nearest TSS
ENST00000381078/Upstream/67162; ENST00000532226/Downstream/4201;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/219127, chr6-CpG: 181/Downstream/3635
Target sequence
ATCTACATAAACTTATATAGCATTTCAGAATTATCAATTCCTTATGTTGAAAAGCTTGATTTCATGGCTAACAGTATCTAGAACAATCTACCAAAATATTCACTAAGCTAGAGGAAGTGGCAGAGTTCCTTAGAGTAATCTTAAAGACAAGCAGCTCCCTCTATAGTCTGTCTGGCCTACTTTGTTTAATTACTTGCTTTGTGGACATCCCACACTCTTCTATTTACTCCTACTCTGCATCTCAGCAGGGAAGCT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate