Basic Information
VIS ID
TVIS30001058
Fusion event
HIV-RPTOR integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
78695664/80721864 (Hg38)
End
78696521/80721864 (Hg38)
Orient
-
Location type
Intronic
Target gene
RPTOR
miRNAs that regulate target gene
hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-155-5p
Nearest miRNA
hsa-mir-10226/Upstream/302371; hsa-mir-1250/Downstream/403412;
Nearest TSS
ENST00000595228/Upstream/12931; ENST00000576366/Downstream/21423;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/176581, chr17-CpG: 30/Downstream/5163
Target sequence
GGAACTCTCTGTGCTGCCTCTGCAACTCTCGTGTACATTTAAAATTATTTCAAATTGTTTTTTAAAAATGCAAACCTAGTTTTGATCCTAACTGCTCTCCAGAAATTACTGAACACATAGTCACCTCTTCACATGCTGCATCCCATGGTCTCTTCCATTCCTGCCCCACCTGACATCTATGCGCCGTCTCCCCTCAAACACACACTCTCTCCCCAGGTCTCCGGCTGTCTCAGCTCATTCTTCCAAAGCTTCCCA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate