Basic Information
VIS ID
TVIS30001064
Fusion event
HIV-STAT5B integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
40421073/42269055 (Hg38)
End
40421248/42269055 (Hg38)
Orient
+
Location type
Intronic
Target gene
STAT5B
miRNAs that regulate target gene
hsa-mir-23b-3p ; hsa-mir-1229-3p ; hsa-mir-93-3p ; hsa-mir-324-3p ; hsa-mir-134-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-335-3p ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-526b-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-4762-5p ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-106b-3p ; hsa-mir-150-5p ; hsa-mir-28-5p ; hsa-mir-182-3p ; hsa-mir-28-3p
Nearest miRNA
hsa-mir-1180/Upstream/751838; hsa-mir-10226/Downstream/225718;
Nearest TSS
ENST00000595228/Upstream/468; ENST00000469124/Downstream/7351;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/84464, chr17-CpG: 126/Downstream/6878
Target sequence
ATAGGCTCTGAATTTATTTAATTTATTTATTTTTTTGAGATGGAGTCTCGCTCCGTCTCCCAGGCTGGAGCACAGTAGTGCGATCTCGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTGCACCACCAC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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