Basic Information
VIS ID
TVIS30001085
Fusion event
HIV-XAF1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
6666199/6762880 (Hg38)
End
6666839/6762880 (Hg38)
Orient
+
Location type
Intronic
Target gene
XAF1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1253/Upstream/107371; hsa-mir-10226/Downstream/254735;
Nearest TSS
ENST00000595228/Upstream/1162; ENST00000321535/Downstream/13343;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/48728, chr17-CpG: 49/Downstream/13006
Nearest cancer related gene
XAF1(TSG, No orient, 0)
Target sequence
TTTACCTTTCTTAACACTTCAGTGCTTAAAACTACAGAATATCAAAACTAAAGAAACCATAGAGACGATCCAGCTTTTCGCTCTTTTCTTTTTCTTTTTACTATTGTGGTAAACCACGTATAATGTAAAATTTGCCATCACTATAGAGACATTTGGTACATTCACAATGTTGTGCAATCTGGTTCTAGAATATTTTCATCATTCCAAAAAGAAATCCTATACCCATTAGCAGGTACTGTACATTCCCTCATCTTC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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