Basic Information
VIS ID
TVIS30001089
Fusion event
HIV-ZNF468 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.41
Reference genome
GRCh37/hg19
Start
53355424/52852171 (Hg38)
End
53355983/52852171 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZNF468
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-155-5p ; hsa-mir-4786-5p ; hsa-mir-6504-5p ; hsa-mir-3064-5p ; hsa-mir-149-5p ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-3976 ; hsa-mir-4662a-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-6845-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-629-3p ; hsa-mir-4279 ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-202-5p ; hsa-mir-3924 ; hsa-mir-1257 ; hsa-mir-3119 ; hsa-mir-627-3p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-1825 ; hsa-mir-4302 ; hsa-mir-5571-5p ; hsa-mir-4452 ; hsa-mir-135b-5p ; hsa-mir-135a-5p ; hsa-mir-889-5p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-2116-3p
Nearest miRNA
hsa-let-7e/Upstream/570278; hsa-mir-10394/Downstream/814508;
Nearest TSS
ENST00000633603/Upstream/2541; ENST00000594546/Downstream/5429;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/65212, chr19-CpG: 20/Downstream/4777
Target sequence
CCTGGCCAACATGGTGAAACTCTGTCTTTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCTGGCACCTGTAATCCCAGCTACTTGAGAGTCTGAGGCAGGAGACTCACTTGAACCCAGGAGGCAGAGGTTTCAGTGAGCCGAGATCATGCCATTATACTCCAACCTGGGCAACAAGAGCAAAACTCAGTCTCAAAAAAATAAATTTTTACAAAAATAACAGCCAGGCATGGTGGCTCACGCCTGTAATCTCA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate