Basic Information
VIS ID
TVIS30001090
Fusion event
HIV-GPC3 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
133063116/133929089 (Hg38)
End
133063900/133929089 (Hg38)
Orient
+
Location type
Intronic
Target gene
GPC3
miRNAs that regulate target gene
hsa-mir-219a-5p ; hsa-mir-520c-3p ; hsa-mir-1271-5p
Nearest miRNA
hsa-let-7f-2/Upstream/12558036; hsa-mir-105-1/Downstream/240289;
Nearest TSS
ENST00000429181/Upstream/175387; ENST00000370809/Downstream/56360;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/512833, chrX-CpG: 29/Downstream/54965
Nearest cancer related gene
GPC3(TSG, No orient, 0)
Target sequence
GTCTTCATCCATTTTAAGTTGATTTTTATGTACAGTATAAGATAAGGGTCCAATTTAATTCTTTTGCATGTGGAAATCCTGTTCTCTCAGCACCATTTATTGAAAAGACTATTCTTTCTCCATTGTGTCCTTTTTGGTGCCCTTGTGGAAAATTAGTTGACCACATATGTTTGGGTTCATTTTTGGGTTCTTGATTCTGTTCCACTGGTTTTCCATATAGTTCTGTATTGTTTCTTTCTTTTTGTTTTTTCATTA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate