Basic Information
VIS ID
TVIS30001111
Fusion event
HIV-CEP152 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
49037423/48745226 (Hg38)
End
49037667/48745226 (Hg38)
Orient
+
Location type
Intronic
Target gene
CEP152
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-1229-3p ; hsa-mir-877-3p ; hsa-mir-454-5p ; hsa-mir-615-3p ; hsa-mir-92b-3p ; hsa-mir-18a-3p ; hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-197-3p
Nearest miRNA
hsa-mir-10393/Upstream/3312097; hsa-mir-11181/Downstream/423844;
Nearest TSS
ENST00000557528/Upstream/3212; ENST00000558304/Downstream/28305;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/98846, chr15-CpG: 16/Downstream/65308
Target sequence
GGGTTTCAACTGTTTCAGATGCTTGTGTTTTGTTTTCCAACTGTGCTGAAGCTCTGTAGAAACCTACTAGGTTTTCTAATTCCATGTTCCCTATGGATCCTGGTAGACAGTTTATGCTCATATAAACGATCATTGAACATGCACCTCGATATAAAACAAAAAGAAAGTTAACCTTAAGTAGGTGTCTTTTTCAGAAATAATGTAAGATTTTCAATTCTTTGAACTTTGTGTGTGTGTGTGTGTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate