Basic Information
VIS ID
TVIS30001112
Fusion event
HIV-DHX29 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
54585400/55289572 (Hg38)
End
54586209/55289572 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
DHX29
Nearest miRNA
hsa-mir-10397/Upstream/117219; hsa-mir-103a-1/Downstream/219278;
Nearest TSS
ENST00000502646/Upstream/13212; ENST00000504388/Downstream/17968;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/55237, chr5-CpG: 60/Downstream/17809
Target sequence
CCTTCTTTTTCCTTGTAGCCAATTATTTAATAATTCCTGTTAGGAATCTGTGCAGGAATCAGAGGCAATTTATTAATTTTCACAACATATACAAAAATTTTAAAATAAATTATTTAATAGGTGCAATAAGCCTGGAAAAACAAACATCTTCATTAAAATAAATACTCATGGAATTGTATTCACCTTTCTCTCTTGAATGACCACGATATTTTATGGTATAAAAATCATAGGTTGGCAAACTATGTCTTGTAGGCC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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