Basic Information
VIS ID
TVIS30001114
Fusion event
HIV-IFT140 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1570920/1520919 (Hg38)
End
1571746/1520919 (Hg38)
Orient
-
Location type
Intronic
Target gene
IFT140
miRNAs that regulate target gene
hsa-mir-93-3p ; hsa-mir-6874-5p ; hsa-mir-6500-5p ; hsa-mir-4633-3p ; hsa-mir-6080 ; hsa-mir-558 ; hsa-mir-6849-5p ; hsa-mir-3681-5p ; hsa-mir-22-3p
Nearest miRNA
hsa-mir-3176/Upstream/750642; hsa-mir-11401/Downstream/214066;
Nearest TSS
ENST00000527434/Upstream/881; ENST00000253934/Downstream/6105;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10726, chr16-CpG: 36/Downstream/3595
Target sequence
CCCGGCCTAAGACATATTCTCAAGTGAAGAATGTAAAATTTTTCTTAAAATGAGGGCTGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGCCCAGCCTGACCAACAGGGAGAAACCCTGTCTCTACTAAAAAAAATTACAAAATTAGCCGGGCATGGTGGCGGGCGCCTGTAATCCCAGCTACTTGGTAGGCTGAGGCAGGAGAATGG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate