Basic Information
VIS ID
TVIS30001123
Fusion event
HIV-MRTFB integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
14305869/14212012 (Hg38)
End
14306658/14212012 (Hg38)
Orient
+
Location type
Intronic
Target gene
MRTFB
miRNAs that regulate target gene
hsa-mir-29c-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-607 ; hsa-mir-3156-3p ; hsa-mir-3671 ; hsa-mir-4433a-5p ; hsa-mir-3907 ; hsa-mir-3145-3p ; hsa-mir-139-5p ; hsa-mir-4735-5p ; hsa-mir-4301 ; hsa-mir-181a-2-3p ; hsa-mir-4762-5p ; hsa-mir-5002-5p ; hsa-mir-5588-3p ; hsa-mir-32-3p ; hsa-mir-6715b-3p ; hsa-mir-1256 ; hsa-mir-8076 ; hsa-mir-3688-3p ; hsa-mir-183-5p ; hsa-mir-190a-5p ; hsa-mir-190b ; hsa-mir-19b-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-1225/Upstream/1491641; hsa-mir-11401/Downstream/91955;
Nearest TSS
ENST00000527434/Upstream/11682; ENST00000571770/Downstream/35399;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/140213, chr16-CpG: 54/Downstream/73455
Nearest cancer related gene
MRTFB(OG, No orient, 0)
Target sequence
CTTATATGACCATTAAGAGCAAAGACTCATCAAGGAGTCATCAGACAGTCCCCTCGGCAATGGAGATTTGCTATGAGTAGTCAGAACTAGTCTGAACTGATATTTGCATTGTCATTTTGTATACAATCGTGTTTTAAATGTCTACTTTATTTGTGAAATACATAATTTTTATCCTGTAACATTTAAGATTTCAAATTTTGCAGGTCTCCTAATGGAACTGGTAAATTAATGGAACTGTAGTTGTGATCTGTTAAT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate