Basic Information
VIS ID
TVIS30001125
Fusion event
HIV-NADK2 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
36217660/36217558 (Hg38)
End
36218612/36217558 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
NADK2
miRNAs that regulate target gene
hsa-mir-484
Nearest miRNA
hsa-mir-10397/Upstream/69570; hsa-mir-103a-1/Downstream/2339944;
Nearest TSS
ENST00000502646/Upstream/4381; ENST00000501794/Downstream/699;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/65281, chr5-CpG: 127/Downstream/23343
Target sequence
GCTACCAAGTGGAAGTATATTTTTGTATACTTACCTAGCAGAATCTGTCCCATTGACTTTCGATACATTGATTATCAGTTTTGAAATCAATTAAACCTGATTGTTTTTTTCCTTTTACCAGAGATGTTATTTAAATTTTTAGGTGTAATCAACACTTTTATTTATTGTTTCTTAATCCTTTTTTCCTTTTATTGTTTTAAAAAACCTCCATTATAAAATTTGTGGAGAGGGATTTTTATCTAATCCAGCCATCTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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