Basic Information
VIS ID
TVIS30001128
Fusion event
HIV-RNF217 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
125384729/125063583 (Hg38)
End
125385692/125063583 (Hg38)
Orient
-
Location type
Intronic
Target gene
RNF217
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-4276 ; hsa-mir-205-5p ; hsa-mir-5190 ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-4482-3p ; hsa-mir-7159-3p ; hsa-mir-138-2-3p ; hsa-mir-6507-5p ; hsa-mir-6833-5p ; hsa-mir-6124 ; hsa-mir-3190-3p ; hsa-mir-3148 ; hsa-mir-4657 ; hsa-mir-4491 ; hsa-mir-4280 ; hsa-mir-576-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-198 ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-4530 ; hsa-mir-590-3p ; hsa-mir-338-3p ; hsa-mir-6818-3p ; hsa-mir-4279 ; hsa-mir-6881-3p ; hsa-mir-6895-3p ; hsa-mir-593-3p ; hsa-mir-6845-3p ; hsa-mir-942-5p ; hsa-mir-877-3p
Nearest miRNA
hsa-mir-10398/Upstream/5048326; hsa-mir-1202/Downstream/1421048;
Nearest TSS
ENST00000381078/Upstream/16983; ENST00000534368/Downstream/55466;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/100340, chr6-CpG: 34/Downstream/36014
Target sequence
ATTTCATTACAATATTTTCACTTATTTCTATTTTATAACTAAGACAACATATTGATTTTTAAAATAAAATATTATAGGTAGTCACATTATATTTAATCTCAGGACCGTAAGCAAGTACTAACATTACTTGTCATAAAAACAGGGCATTGGATACAATGTAGTTAATATCCTCCAAAGTATGTGCCGTCAAACAATCATGCTTCTAACAACTAAGGTCTAGAGTTTGGCATACCATAAAAACAGTGCCAATGATAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate