Basic Information
VIS ID
TVIS30001132
Fusion event
HIV-VPS41 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
38897626/38858026 (Hg38)
End
38898532/38858026 (Hg38)
Orient
+
Location type
Intronic
Target gene
VPS41
miRNAs that regulate target gene
hsa-mir-148a-3p ; hsa-let-7b-5p ; hsa-mir-197-3p ; hsa-mir-4634 ; hsa-mir-4695-3p ; hsa-mir-6787-3p ; hsa-mir-6511b-3p ; hsa-mir-6511a-3p ; hsa-mir-6736-3p ; hsa-mir-4714-3p ; hsa-mir-652-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-1183/Upstream/1938594; hsa-mir-10399/Downstream/4292869;
Nearest TSS
ENST00000635602/Upstream/26680; ENST00000464276/Downstream/51148;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/226465, chr7-CpG: 36/Downstream/117917
Target sequence
GTTGTGAGGACCAAGGTTCTTACTATGTAGAAGAAGTCTTATAGGTGGCACCCTTAGAGGTAATATACGGCAAACGTTTCCTATTCAGACCTTTAAGCTACTCTCTTCAGGATCAGAAAAAGACCTGGAAAGGGAAGGGGATTCTCTACAGAATGTAAATTTTCCCCAAAAGAGACAGCTTTGCACAGCTATTTCAAAATATGCCAAAGAAATATATATTAGGGCAAAATACTTTGACTTCTTTCAGGGCTTGCT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate