Basic Information
VIS ID
TVIS30001141
Fusion event
HIV-ADAM10 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
58901765/58609566 (Hg38)
End
58902487/58609566 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADAM10
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-155-5p ; hsa-mir-484 ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-451a ; hsa-mir-103a-3p ; hsa-mir-448 ; hsa-mir-655-3p ; hsa-mir-449a
Nearest miRNA
hsa-mir-10393/Upstream/3236532; hsa-mir-11181/Downstream/561617;
Nearest TSS
ENST00000557528/Upstream/22059; ENST00000559745/Downstream/11938;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/542988, chr15-CpG: 125/Downstream/139316
Target sequence
GTGAGTTATAAGTCAATTTCCAAAGCAAACTACATTCAGTTCAATTATAGCACATTCTCAAATATATCATTTGCAAGCTTCCTATAGATATTTTAATGTTATCACTTTTAAAGCATGAACACTTAAGTTGAGATAGTCAATCTTGACAATCTTTTAAGAAAACATCAGGTAATTCTGTGTTTGTACAACTTGGAGATGTGTGGGCTTAAAAATAAGCGTTCAGTGGATTACTGCTGGATGAACTTCCATAATCAT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate