Basic Information
VIS ID
TVIS30001144
Fusion event
HIV-C2CD3 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
73823305/74112260 (Hg38)
End
73824134/74112260 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
C2CD3
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10392/Upstream/1328668; hsa-let-7a-2/Downstream/286977;
Nearest TSS
ENST00000527297/Upstream/1672; ENST00000542710/Downstream/21370;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/128503, chr11-CpG: 58/Downstream/58594
Target sequence
TATACCACATTTCATTTATCCTTTTCTCAGTTGCTGGACATTCGTGTTATTTCCACTTCCTGGCAATTTTGCATAATGCTGCTATGTGAACATTTGTGTACGTGGTTTTGTATGGACTGTGTGCTTTCATTTCCCTTGGGTATATATCTAATGGTAGAATTGCTGGGTCATATGGTAACTTTATGTTTTAACTTTTTCAAGAACTGCCAGACTGTTTTCAACAGTGGCTGCACCATTTTCCCACTAGCAGTATAT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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