Basic Information
VIS ID
TVIS30001147
Fusion event
HIV-CDYL integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
4877236/4877002 (Hg38)
End
4878031/4877002 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6B
Target gene
CDYL
miRNAs that regulate target gene
hsa-mir-141-3p
Nearest miRNA
hsa-mir-4645/Upstream/2022895; hsa-mir-10398/Downstream/271231;
Nearest TSS
ENST00000381078/Upstream/40904; ENST00000469671/Downstream/12990;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/99686, chr6-CpG: 41/Downstream/126749
Target sequence
AAAGCAATCTTGAAAAAGAAGTACTAAGTAGGGCTCCTACAACCTATTTCAAGATATAACATCATAAAGCAACAGATTTCAAGGAAAAGCAGTACCTGTGTAAGTATCTACAAAGACATCAATGAAACAAGAGAGCACCAGAAATAGATTTTCATTTATGATTCTAAATTACACAACTGATTTTTGATTACAAAGATCCCCAAGAAATCTATTTGGTCAAGTTTTTTGGAAAAATGTAGCTGGGATACTGGATAT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate