Basic Information
VIS ID
TVIS30001171
Fusion event
HIV-PRPF39 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
45558615/45089412 (Hg38)
End
45559478/45089412 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRPF39
miRNAs that regulate target gene
hsa-mir-21-5p
Nearest miRNA
hsa-mir-208a/Upstream/8137021; hsa-mir-1185-1/Downstream/2671583;
Nearest TSS
ENST00000550708/Upstream/5284; ENST00000556353/Downstream/5809;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/126500, chr14-CpG: 46/Downstream/44758
Target sequence
CCAAGTTTAATCACTTCAGGCCCTAGGAAAAGGCAAAGTAACTTGTAAATTTATTTTGTTCTTTTTCCCTCTTCCTTTAAAGAAAAAGATACGTTTGAAGATTAATTTTCCAAATGCAAATTAGTCACTAGTTTGTGGTTTTGTATTTCAGAGCTCAGTCTAAAAACAAAATACAAAAAAGACTGTAGGCTGATACATTCTGAGTCATTAACTAGCTACCCTATTCTAATTTCACACTTAGGTGAGACATAAGGG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate