Basic Information
VIS ID
TVIS30001172
Fusion event
HIV-PTER integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
16497780/16455781 (Hg38)
End
16498561/16455781 (Hg38)
Orient
+
Location type
Intronic
Target gene
PTER
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-29c-5p
Nearest miRNA
hsa-mir-1265/Upstream/2019120; hsa-mir-107/Downstream/1389326;
Nearest TSS
ENST00000439456/Upstream/18797; ENST00000485788/Downstream/28554;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/18477, chr10-CpG: 195/Downstream/63824
Target sequence
CTTTACCTATGAAGTGAAAAATAATTTCAAAGGAAGGACAGCTAATTTTGTGTTTGTAATAGGTTTATACTGGATTGCTCCACAGCTTGTTGGTAAAAGTAACTTTGAGCACTTAGAGAACACATCTTTATACTTAGTGTGTTCCAATTTAAAAAGTGTTATTACTTTTTTTTTGGAAACCGAGCATCTAAGTAATTCTGAGTTCTCCCAGGCCAACAGAAACTGAGACAGGGAAAATGAACAACCATCATCCCC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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