Basic Information
VIS ID
TVIS30001173
Fusion event
HIV-R3HDM1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
136424841/135667271 (Hg38)
End
136424976/135667271 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2F
Target gene
R3HDM1
miRNAs that regulate target gene
hsa-mir-320a
Nearest miRNA
hsa-mir-128-1/Upstream/1793; hsa-mir-10b/Downstream/4919355;
Nearest TSS
ENST00000437798/Upstream/22038; ENST00000445855/Downstream/8127;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/135422, chr2-CpG: 119/Downstream/74304
Target sequence
AGTTTATATTGTCCTAGTTCTCTTAGCTTGCAGAATTGATTGTGCTTTCCTCTGAAAGTGCTGAAAGAAATGGGATAATATTGCAACAGTGCAGTCCTTTAACAAAACAGAATGGTAGTGTTTTAAAAAAAAAAAAAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate