Basic Information
VIS ID
TVIS30001174
Fusion event
HIV-SEC14L1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
75151428/77155346 (Hg38)
End
75151802/77155346 (Hg38)
Orient
-
Location type
Intronic
Target gene
SEC14L1
miRNAs that regulate target gene
hsa-mir-320c ; hsa-mir-708-5p ; hsa-mir-320a ; hsa-mir-92a-3p ; hsa-let-7c-3p
Nearest miRNA
hsa-mir-10226/Upstream/65849; hsa-mir-1250/Downstream/241638;
Nearest TSS
ENST00000595228/Upstream/10700; ENST00000590483/Downstream/25691;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/13698, chr17-CpG: 18/Downstream/58031
Target sequence
GGTGCAGGCACTTCATCATTTGAAACTTGCAGGCAGCACAGTCAAGTTTACAATGTACCGATCTCTCTGGCAGCAGCCCCAAGGAAGAGCAGAAGAGTGAGGGGTAGACTCAGGGTCCAGAGGCTGTTGTAAGGAGGAGTGGTCTGGGGCTAAGCCACCAAGGCTACAGAAGAGCAAAGTGAGCGCCCATCCAGGAGACATCTCTGCCAGCTCCCATCTGGGCACCAGCAAGACTGAGGGGTGAGGAAGGAAGGC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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