Basic Information
VIS ID
TVIS30001176
Fusion event
HIV-SMAP1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
71415992/70706289 (Hg38)
End
71416906/70706289 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
SMAP1
miRNAs that regulate target gene
hsa-mir-25-3p
Nearest miRNA
hsa-mir-10398/Upstream/13316077; hsa-mir-10524/Downstream/670671;
Nearest TSS
ENST00000381078/Upstream/37759; ENST00000445046/Downstream/66640;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/37814, chr6-CpG: 177/Downstream/249368
Target sequence
CAAATGTTCCATGCTTATGTGATCAAAATATGACAAAATCTCATGAATCCAAATTCCAGTACATCATAATTGGAATAAAGTTACTCTAATAGTATAAAACTAACATATAACAAGAGAAACCATTAATGTCAAAAACAGCTGATACATAAAAACTATTGATAAAAATCAAAGAAAAACCCAGAATAAGGAAGGACAAACATATGTGGCAAAATACAAAACAGCTATATTCCTAATCCTAAATTTTATTCTAACATC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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