VISDB - VIS Detail

Basic Information

VIS ID

TVIS30001177

Fusion event

HIV-TRAPPC10 integration

Validated

Yes

Detection method

QiaQuick PCR and Sequencing

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

25011556

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr21

Cytoband

q22.3

Reference genome

GRCh37/hg19

Start

45509895/44090014 (Hg38)

End

45510649/44090014 (Hg38)

Orient

Location type

Intronic

Target gene

TRAPPC10

miRNAs that regulate target gene

hsa-mir-186-5p ; hsa-mir-330-5p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-193b-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-4713-5p ; hsa-mir-2116-3p ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-4762-5p ; hsa-mir-4753-3p ; hsa-mir-130b-5p ; hsa-let-7a-5p ; hsa-let-7b-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-1233-5p ; hsa-mir-1249-5p ; hsa-mir-1294 ; hsa-mir-1321 ; hsa-mir-149-3p ; hsa-mir-202-3p ; hsa-mir-3921 ; hsa-mir-4278 ; hsa-mir-4316 ; hsa-mir-4419a ; hsa-mir-4458 ; hsa-mir-4468 ; hsa-mir-4500 ; hsa-mir-4510 ; hsa-mir-4653-5p ; hsa-mir-4682 ; hsa-mir-4685-5p ; hsa-mir-4716-3p ; hsa-mir-4723-5p ; hsa-mir-4728-5p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-503-5p ; hsa-mir-5088-5p ; hsa-mir-5698 ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6732-5p ; hsa-mir-6785-5p ; hsa-mir-6794-5p ; hsa-mir-6797-5p ; hsa-mir-6805-5p ; hsa-mir-6825-5p ; hsa-mir-6837-5p ; hsa-mir-6870-5p ; hsa-mir-6883-5p ; hsa-mir-7111-5p ; hsa-mir-760 ; hsa-mir-98-5p

Nearest miRNA

hsa-let-7c/Upstream/480025; hsa-mir-6815/Downstream/1388252;

Nearest TSS

ENST00000624081/Upstream/254; ENST00000485621/Downstream/1739;

Nearest CpG islands

None/Target, chr21-CpG: 261/Upstream/76917, chr21-CpG: 103/Downstream/17061

Target sequence

GTTTCCAAATTATCCACACATCATCAATGGATAAAAAGTTGTGGTGAGAGGCCAGGCTAGCATCCCGAGCCCATTGATCAACGCTAGCACCGTCACTAAGGTAGGACACCTGGACACCGTGGGCCTCCCGGTGCAGTCAACAGGAAGCACACAGCCCCGCCTGCCTCAAAGCAGAACTGGAGTCTACTCAAGCCTTTAGGGCAGCTGTTTTCCACTGGGGCACGTCCGCCCCACCCAGAGGACACTGGGCAGTGT

Reference

Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.