Basic Information
VIS ID
TVIS30001178
Fusion event
HIV-TRAPPC11 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
184586124/183664971 (Hg38)
End
184586247/183664971 (Hg38)
Orient
-
Location type
Intronic
Target gene
TRAPPC11
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-12113/Upstream/1495593; hsa-mir-3945/Downstream/1186042;
Nearest TSS
ENST00000502981/Upstream/954; ENST00000513600/Downstream/1922;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/5480, chr4-CpG: 63/Downstream/57790
Target sequence
AAAGAAAGAAAAGAAAAATAATCGTGTGAGGGCCAGGGCTGGGATGCTATTACTTGCACAATTTCAGAGAGCTCAGTTTCCAGGGCTGAGTATATGAAATGTTGTCGTGTGGTTCTCAAACAC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate