Basic Information
VIS ID
TVIS30001195
Fusion event
HIV-WASHC3 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
102427639/102033861 (Hg38)
End
102428485/102033861 (Hg38)
Orient
+
Location type
Intronic
Target gene
WASHC3
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-let-7i/Upstream/1843912; hsa-mir-1178/Downstream/1896564;
Nearest TSS
ENST00000382841/Upstream/71471; ENST00000552707/Downstream/6573;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/155838, chr12-CpG: 41/Downstream/27781
Target sequence
GTAAACTACTCAAGGTCATACTAATGGACAAATTAGAACTCATTTAAAGAATTATGTTGTTATCGGTCTTTCTCTGCATTAAGAACTAAAACTGAATTTTGAGTGGTGGGTAAGCAAATGTTAGTCACCCCTAAAGTTGAGAAAAATTAGGTATTTTAATACATATCTAAAATCTTGTTGGGAAAGTGAAACACTTTTCAGTATGATAAGGTAGTCTGTAATGAAGTCACCCTCTAGAATTAGCTGGGGTTAGGC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate