Basic Information
VIS ID
TVIS30001196
Fusion event
HIV-DPYD integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
98187634/97722078 (Hg38)
End
98188472/97722078 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1M
Target gene
DPYD
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-302b-3p ; hsa-mir-494-5p
Nearest miRNA
hsa-mir-101-1/Upstream/3178299; hsa-mir-11399/Downstream/323164;
Nearest TSS
ENST00000473358/Upstream/424; ENST00000431362/Downstream/74843;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/999815, chr1-CpG: 47/Downstream/198555
Target sequence
CTCAGGTTATCCTCCATTTAACTAAATTAAAAGCAGCCAGAGCTTTCATTATTTTTGGAACATATTATTTTCTGAAAAAAGAATGAATAATAAGCTGAATATTTGGGAGAATGTTTTCCTCTAATCAAAAGGAAGAATTGCATCTGACCAGTACTCCTGAAAACAATCAAGTACATCAAAAACAAGAAAAGTCTGGCAAATTTTAACAGACAAGAGAAGCCTAAGGACACATGACAAATAAATGTATTGTGGTGA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate