Basic Information
VIS ID
TVIS30001197
Fusion event
HIV-GNAI1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
79842022/80212706 (Hg38)
End
79842757/80212706 (Hg38)
Orient
+
Location type
Intronic
Target gene
GNAI1
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-1-3p ; hsa-mir-320a ; hsa-mir-320c ; hsa-mir-320d ; hsa-mir-9-3p ; hsa-mir-4719 ; hsa-mir-8485 ; hsa-mir-676-5p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-409-5p
Nearest miRNA
hsa-mir-10525/Upstream/4297437; hsa-mir-10399/Downstream/11991309;
Nearest TSS
ENST00000635602/Upstream/25647; ENST00000478292/Downstream/99750;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/77133, chr7-CpG: 59/Downstream/706284
Target sequence
CTATTACAGAACCGAATGCATGAAAGCATGAAATTGTTTGACAGCATATGTAACAACAAGTGGTTTACAGATACATCCATTATACTTTTTCTAAACAAGAAGGATCTCTTTGAAGAAAAAATCAAAAAGAGCCCTCTCACTATATGCTATCCAGAATATGCAGGTATTTTCCTTTTCTGGGAATAACTTGTCAAGTTACATATTTCTAAGTGAAACTTCCCCTAAGGCAAGAATTCAGTTGTTAATTTAAATCTC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate