Basic Information
VIS ID
TVIS30001199
Fusion event
HIV-MAP4K5 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
50906928/50440210 (Hg38)
End
50907828/50440210 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAP4K5
miRNAs that regulate target gene
hsa-mir-4639-5p ; hsa-mir-3121-5p ; hsa-mir-4667-3p ; hsa-mir-548at-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n
Nearest miRNA
hsa-mir-208a/Upstream/140264; hsa-mir-1185-1/Downstream/3508217;
Nearest TSS
ENST00000550708/Upstream/1809; ENST00000555257/Downstream/8597;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/43046, chr14-CpG: 109/Downstream/91649
Target sequence
ATCAGTTTAAACTTATTAATTCTTATTTTATTCCATGCGATATGATCTATCTCTATTATTTATTTTCACACTTAAATTGTCCCAGAATTTTTGAGCAGTGGGAATGCCTGTGTTCTTTTGTTTGAAATGTCCTCATCATTTTTTAGCACTTCTTTACTTTCTGGCACAGCAAGATTTCTAGGCTCAGCATCTACTTTTATTGCCCCAGAATTGGAAGCAGTCTTTCTCTAAGAAGCCCTGGTTCTTTTTAGTGGA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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