Basic Information
VIS ID
TVIS30001213
Fusion event
HIV-PIK3C3 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
39585285/42005321 (Hg38)
End
39586227/42005321 (Hg38)
Orient
-
Location type
Intronic
Target gene
PIK3C3
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-149-5p ; hsa-mir-3978 ; hsa-mir-4709-3p ; hsa-mir-6124 ; hsa-mir-3148 ; hsa-mir-4699-5p ; hsa-mir-4635 ; hsa-mir-5579-5p ; hsa-mir-5583-3p ; hsa-mir-129-5p ; hsa-mir-29b-2-5p ; hsa-mir-5087 ; hsa-mir-659-3p ; hsa-mir-8068
Nearest miRNA
hsa-mir-1-2/Upstream/2328542; hsa-mir-122/Downstream/2964761;
Nearest TSS
ENST00000575820/Upstream/47654; ENST00000590013/Downstream/20010;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/2163456, chr18-CpG: 180/Downstream/2673697
Target sequence
GGGACAGAAGCTCCTGTGCTCAGGACCTCAACCCATGTGTCATTTCAACTAGCTGTTCATCTGCAACCTTTAGGATACCCTTCATAATAAATCAATAGTAGTAAGTAATGTTTTCCTGAGTTTTGTGAGTCATTCTGGCAAATTATCATTTCATCTAGCTGTTCTTCTGTATCCTTTAGGATACCCTTCATAATAAATCAATAGTAAGTAATGTTTCCCTGAGTTTTGTGAGTCATTCTAGCAAATTATCACACC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate