Basic Information
VIS ID
TVIS30001214
Fusion event
HIV-PTPN13 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
87675440/86754287 (Hg38)
End
87676361/86754287 (Hg38)
Orient
+
Location type
Intronic
Target gene
PTPN13
miRNAs that regulate target gene
hsa-mir-200c-3p ; hsa-mir-194-5p ; hsa-mir-331-3p ; hsa-mir-186-5p ; hsa-mir-92a-3p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-12113/Upstream/211735; hsa-mir-1243/Downstream/546208;
Nearest TSS
ENST00000502981/Upstream/119035; ENST00000508063/Downstream/4382;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/159468, chr4-CpG: 72/Downstream/137732
Nearest cancer related gene
PTPN13(TSG, No orient, 0)
Target sequence
GCTTTCTAGTGATCAAACTCCTTACATGGACTGAATTTAGAATGCCTATATACCTGAAATACCTTAGTTATTAACATGTCCATATGGTAGTAATTATTGACTAACAGTTATTTAGTGCTTACTATGTGTCAAGCACTGTTCTAAGCACTTTTTATTATTTCTCATTTAATGCCCACAACAACCCTATGAGGTAGGTGTTAATGTTATTTTTTTTCACACGTAAGAAACCAAAGCATAGAGAGTTAAGTTGTACAG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate