Basic Information
VIS ID
TVIS30001215
Fusion event
HIV-RASA2 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
141269141/141550299 (Hg38)
End
141270079/141550299 (Hg38)
Orient
-
Location type
Intronic
Target gene
RASA2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-182-5p ; hsa-mir-203a-3p ; hsa-mir-4470 ; hsa-mir-3973 ; hsa-mir-4635 ; hsa-mir-548l
Nearest miRNA
hsa-let-7g/Upstream/7112393; hsa-mir-1224/Downstream/10015577;
Nearest TSS
ENST00000440867/Upstream/63215; ENST00000505833/Downstream/28225;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/62381, chr3-CpG: 56/Downstream/109577
Target sequence
AAAAGGATCAAACTGTTTCTAAGTAACTTAACCAAGTGCCGAACAAAGCTCAAGTACATTCATAGAAATATTAAAATATCCAGCAACTTCACAATGTCTGGCATGCAACAGAAAATAACCAGGAATGCAAGGAACTAAGAAATTATGATCCATAATGAAAAGAAAAATCAATAGAAACAGAATCAGAAATGACAAAGAAGACAGAACTAGCAGACAAAGACATTTAAAAGTTATAATTATATTCCATATGATCCA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate