Basic Information
VIS ID
TVIS30001219
Fusion event
HIV-STAT5B integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
40376809/42224791 (Hg38)
End
40377642/42224791 (Hg38)
Orient
+
Location type
Exonic
Target gene
STAT5B
miRNAs that regulate target gene
hsa-mir-23b-3p ; hsa-mir-1229-3p ; hsa-mir-93-3p ; hsa-mir-324-3p ; hsa-mir-134-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-335-3p ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-526b-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-4762-5p ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-106b-3p ; hsa-mir-150-5p ; hsa-mir-28-5p ; hsa-mir-182-3p ; hsa-mir-28-3p
Nearest miRNA
hsa-mir-1180/Upstream/707574; hsa-mir-10226/Downstream/269982;
Nearest TSS
ENST00000595228/Upstream/6920; ENST00000592536/Downstream/43796;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/40200, chr17-CpG: 126/Downstream/51142
Target sequence
CGGACCAACCTCTGTTCATTGTACAATATATGGCGGATGCAGCGGACCAGCTCCATGGGGCAGCGGTCATACGTGTTCTGAAAGAATCCAACAGCAGACATCACTTTGTGCCACTCCACACTATGGGCCCTAACCATGCCTCAGGATGGGGAGCCTCCTGAGGGACCTCCTGAATCACAGGAGGCACTGTTCCTCCAATACCAACAGGAACAAGAAGGCACATCATGGAAATCCAATTGCAGTGAAAAGGTAAGA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate