Basic Information
VIS ID
TVIS30001220
Fusion event
HIV-WDR90 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
713133/663133 (Hg38)
End
713820/663133 (Hg38)
Orient
+
Location type
Intronic
Target gene
WDR90
Nearest miRNA
hsa-mir-3176/Upstream/119767; hsa-mir-11401/Downstream/107050;
Nearest TSS
ENST00000527434/Upstream/858; ENST00000548448/Downstream/7;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/86, chr16-CpG: 103/Downstream/4798
Target sequence
AATTGTCAAAGAAATCACATCAGTCCGGGCGTGGTGGTTCATGCCTGTGATCCCAGCACTCTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGTCAACATGGCGAAATCCCATCTCTACTGAAAATAC:AAAAATTAGCCGGGCCTCTTGATGTATACCTGTAATCCCAGCTACTCTGGAGGCTGAGACAAGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAACCA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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