Basic Information
VIS ID
TVIS30001236
Fusion event
HIV-SEPTIN7 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
35891065/35851455 (Hg38)
End
35891962/35851455 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7C
Target gene
SEPTIN7
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-429 ; hsa-mir-200a-3p ; hsa-mir-200c-3p ; hsa-mir-141-3p ; hsa-mir-200b-3p ; hsa-mir-26b-5p ; hsa-mir-34a-5p ; hsa-mir-135a-3p ; hsa-mir-296-3p ; hsa-mir-127-3p ; hsa-mir-587 ; hsa-mir-5581-3p ; hsa-mir-223-5p ; hsa-mir-4716-5p ; hsa-mir-511-3p
Nearest miRNA
hsa-mir-1183/Upstream/910621; hsa-mir-10399/Downstream/1067902;
Nearest TSS
ENST00000635602/Upstream/4610; ENST00000473201/Downstream/12097;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/49474, chr7-CpG: 87/Downstream/115946
Target sequence
CAAAGGTTATAGTAGTCCATTAGAGCTTAAAATTTCCTTGAAATCTCTTATCTCAGTTCCATCAATAAACTTTTCTTGTGACCTTGGGCAAACCATACTTCTGTGTGTCAGTGCCCTCACCTATGAAATGCAGATAAAAGCAGTACCTACAACAACACAGAGTTGGTGTGAGGAATAAGTGATCTCATTAGAATCATACCTTGGCACAGTGGACACCTGAATATCAGTAATAGGTAGTTGCAATGAAATGTATTT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate