Basic Information
VIS ID
TVIS30001237
Fusion event
HIV-ADK integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
76441610/74681852 (Hg38)
End
76442001/74681852 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADK
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-5571-5p ; hsa-mir-4674 ; hsa-mir-6878-3p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-6749-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-4437 ; hsa-mir-4757-5p ; hsa-mir-6744-3p ; hsa-mir-378g ; hsa-mir-4680-5p ; hsa-mir-532-3p ; hsa-mir-212-5p ; hsa-mir-6513-3p ; hsa-mir-1224-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-6813-3p ; hsa-mir-498 ; hsa-mir-592 ; hsa-mir-4279 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-597-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-1914-5p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p
Nearest miRNA
hsa-mir-1265/Upstream/1960752; hsa-mir-107/Downstream/870606;
Nearest TSS
ENST00000439456/Upstream/151299; ENST00000604130/Downstream/140278;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/504622, chr10-CpG: 35/Downstream/131585
Target sequence
CCCATCAATTTAAAAATGATCTTAATTTCGGAAGAAAGCTCTTGAAGAGTACTGCTAAGCAGTATTTTGCACTCATATAGATAAGATGCCCTTTCACCCTAATCCCTTTCAAAACACTGCTTTAAAAGTCATTCTTCTTCATGGAGCATAGATGTACAACACTGAGTCAGTATTTGATTTTAAAGCTAATGTGTGATCTTTTGATGTGGTTCCCAAAATAAAAGTTTAGCGTATGCTTCTGTTTATTGTTAAAGT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate