Basic Information
VIS ID
TVIS30001239
Fusion event
HIV-ALMS1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
73625891/73398763 (Hg38)
End
73626320/73398763 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
ALMS1
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-375 ; hsa-mir-21-5p ; hsa-mir-99b-3p ; hsa-mir-92a-3p ; hsa-mir-22-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/3145758; hsa-mir-10b/Downstream/1692049;
Nearest TSS
ENST00000437798/Upstream/12894; ENST00000476650/Downstream/52934;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/12230, chr2-CpG: 31/Downstream/338428
Target sequence
TTGACTTTTATATATTAACCTATATTCTGCAGTTTTGCTAGTTTTACTTATTAATTCCAGGAAAGTTTTGTCAGTTCTTTTGGATTTTCTTTTTTTTTGAGATGGAGTCTGGCACTGTCACCCGGGCTGGAGTGCAGTGGTGTGATCTCAGCTTACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCGCCTGCCACCATGCCTGGCTAATTTTTGTT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate