VISDB - VIS Detail

Basic Information

VIS ID

TVIS30001240

Fusion event

HIV-ANKRD13C integration

Validated

Yes

Detection method

QiaQuick PCR and Sequencing

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

25011556

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr1

Cytoband

p31.1

Reference genome

GRCh37/hg19

Start

70786459/70320776 (Hg38)

End

70786491/70320776 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA1L

Target gene

ANKRD13C

miRNAs that regulate target gene

hsa-mir-29c-3p ; hsa-mir-122-5p ; hsa-mir-181a-5p ; hsa-mir-374a-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-20b-5p ; hsa-mir-219a-2-3p

Nearest miRNA

hsa-mir-101-1/Upstream/2137166; hsa-mir-11399/Downstream/746855;

Nearest TSS

ENST00000473358/Upstream/6986; ENST00000486110/Downstream/4181;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/115017, chr1-CpG: 84/Downstream/33274

Target sequence

CTATAATACTTTACTTTTTTCTTTTTTTTTTT

Reference

Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.