Basic Information
VIS ID
TVIS30001241
Fusion event
HIV-ANKRD44 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
198168611/197303887 (Hg38)
End
198169499/197303887 (Hg38)
Orient
+
Location type
Intronic
Target gene
ANKRD44
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-335-3p ; hsa-mir-1277-5p ; hsa-mir-4789-5p ; hsa-mir-190a-3p ; hsa-mir-3941 ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-3171 ; hsa-mir-380-3p ; hsa-mir-383-5p ; hsa-mir-5096 ; hsa-mir-6513-3p ; hsa-mir-129-5p ; hsa-mir-7158-3p ; hsa-mir-4502
Nearest miRNA
hsa-mir-10b/Upstream/8170776; hsa-mir-1244-1/Downstream/9479347;
Nearest TSS
ENST00000437798/Upstream/105849; ENST00000442984/Downstream/6759;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/139173, chr2-CpG: 97/Downstream/6047
Target sequence
GGCTACCAACATATTTACAAACATAAACACTGATAAGGGCAAATACCTGCATTCCCGACCTCTGAAAGCAGCCAAAGCCAAATAATATATTGGTTAAAAGGTTAAAAAGGAGTAATCTATAAAGAGGGCAATCTTAGGCCAGGTGTGGTGGCTTACCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCACATGAGGCCAGGAGTTTGAGACCAGCCTGGCCGACATGGTGAAACCTCATCTCTAC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate