Basic Information
VIS ID
TVIS30001246
Fusion event
HIV-CD3E integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
118178409/118307694 (Hg38)
End
118178791/118307694 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
CD3E
miRNAs that regulate target gene
hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-6090 ; hsa-mir-4430 ; hsa-mir-6797-5p ; hsa-mir-3652 ; hsa-mir-1249-5p ; hsa-mir-3135b ; hsa-mir-4772-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-4781-5p ; hsa-mir-4779
Nearest miRNA
hsa-mir-10392/Upstream/4857606; hsa-let-7a-2/Downstream/336306;
Nearest TSS
ENST00000527297/Upstream/2795; ENST00000531913/Downstream/4450;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/154215, chr11-CpG: 22/Downstream/51755
Target sequence
CTGCCTCAGCTTCTCGAGTAGCTAGGACTACAGGCGTACACCACCATGTCTGGCTGATTTTGGTATTTTTAGTAGAGACGGGGTTTCGCCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCATGGTGTCCAGCCATGGTTGCCATTAAATACAACATTGGTTCACTCAGTTTGGAAGAGCTGATTGAATAGAGGGGCTT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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