Basic Information
VIS ID
TVIS30001249
Fusion event
HIV-DDX17 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
38895901/38499896 (Hg38)
End
38896020/38499896 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
DDX17
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-155-5p ; hsa-mir-744-5p ; hsa-mir-18a-3p ; hsa-mir-331-3p ; hsa-mir-106b-5p ; hsa-mir-27b-3p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-378c ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-432-3p ; hsa-mir-377-3p ; hsa-mir-218-5p ; hsa-mir-539-3p ; hsa-mir-6883-3p ; hsa-mir-3606-5p ; hsa-mir-3613-5p ; hsa-mir-142-3p ; hsa-mir-6073 ; hsa-mir-1266-3p ; hsa-mir-454-5p ; hsa-mir-190a-3p ; hsa-mir-5690
Nearest miRNA
hsa-mir-1286/Upstream/511043; hsa-let-7a-3/Downstream/2313987;
Nearest TSS
ENST00000624155/Upstream/4850; ENST00000475924/Downstream/6005;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/31638, chr22-CpG: 145/Downstream/5652
Target sequence
GCTCCCACCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACTCCGTCTCTACTGAAAAAAAAAAAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate