Basic Information
VIS ID
TVIS30001250
Fusion event
HIV-DET1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
89070336/88527105 (Hg38)
End
89071177/88527105 (Hg38)
Orient
+
Location type
Intronic
Target gene
DET1
miRNAs that regulate target gene
hsa-mir-155-5p
Nearest miRNA
hsa-mir-10393/Upstream/580837; hsa-mir-1179/Downstream/81002;
Nearest TSS
ENST00000557528/Upstream/21318; ENST00000560174/Downstream/9229;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/59104, chr15-CpG: 100/Downstream/77324
Target sequence
CTATCTCCCATCATCTCCTCTCCTATTCTCTTTGTTCTTACAGAACAAAGAGTTCTATACTTTGTTTATACCTCTAATGTTTATACCTCTTATTCCTTTATTGTCATTTGAGTGGGACTTAGGGATGGAGCAAAGATAAATACATGTGTTCAACATATCATGTTTAACCAAAAGTTTCTAAAATGATTTTCTTATTCATTCAATAAACATAAGTGCTTGACAGTGTACCACTGAAGATATAGCAATACATGAAGA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate