Basic Information
VIS ID
TVIS30001251
Fusion event
HIV-DNM3 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
172176589/172207449 (Hg38)
End
172177178/172207449 (Hg38)
Orient
+
Location type
Intronic
Target gene
DNM3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/62805; hsa-mir-1182/Downstream/3760921;
Nearest TSS
ENST00000473358/Upstream/62655; ENST00000491124/Downstream/171569;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/365264, chr1-CpG: 35/Downstream/236278
Target sequence
GTTTTATTTCTTATTTTTGTTCTAGAAACATTTGTTTAGCATTTACCATGTGTCAGGTGCTCAGCATTCAAAGGTAGGCAGGACATGAACTCTGCTTTCAAGGCAGAGTAACAGGGAGAGCAACAGGAGAAAGGCATTGAATTTGGTTCTCAGATTTATACTGCTTTTATTTTCTGTATTTTGAAATTTGGAAGTTAAGTGAGTTTTCTTGTTTCTTTGTTTTTATGTGTATGCTTTATTAATGAATGCTTAGAT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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