Basic Information
VIS ID
TVIS30001252
Fusion event
HIV-DST integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
56361031/56496233 (Hg38)
End
56361296/56496233 (Hg38)
Orient
+
Location type
Intronic
Target gene
DST
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-32-5p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-218-5p ; hsa-mir-26a-5p ; hsa-mir-3130-3p ; hsa-mir-485-3p ; hsa-mir-539-3p ; hsa-mir-136-5p ; hsa-mir-127-5p ; hsa-mir-432-5p ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-7156-3p ; hsa-mir-500a-3p ; hsa-mir-6882-3p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-6804-3p ; hsa-mir-1468-3p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-545-3p ; hsa-mir-8063 ; hsa-mir-548p ; hsa-mir-4460 ; hsa-mir-4662a-5p ; hsa-mir-3119 ; hsa-mir-140-5p ; hsa-mir-6718-5p ; hsa-mir-203b-5p ; hsa-mir-553
Nearest miRNA
hsa-mir-10398/Upstream/3219162; hsa-mir-10524/Downstream/893899;
Nearest TSS
ENST00000381078/Upstream/3990; ENST00000426453/Downstream/1501;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/62817, chr6-CpG: 38/Downstream/46433
Target sequence
GTAGCCTAAATTTAATTTCACAGTCCCCATTTCTATGAAAGAAAGCCCACATTTCAAGTCTCATCATTTTTTCCTCATCTTTCTTAGGAGCCAACTGTGTCACATGATCTAGGTAGGAACAGCGCACAGGTACAACACTCCAGACTGGACAGTTAAACAGAAGCCTCCTCTTTGTGTCTGTATTTGGTGTAAGTATGAAGTTGAAGATAAAGCTCTATCACCATTAAAACAAAAAAGGAAGTTTTTTTTTTTTAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate