Basic Information
VIS ID
TVIS30001255
Fusion event
HIV-FRMD8 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
65180154/65412683 (Hg38)
End
65180567/65412683 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA11H
Target gene
FRMD8
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-874-3p ; hsa-mir-377-5p ; hsa-mir-4257 ; hsa-mir-4524a-3p ; hsa-mir-6086 ; hsa-mir-6516-5p ; hsa-mir-6864-3p ; hsa-mir-455-3p ; hsa-mir-3672 ; hsa-mir-6499-3p ; hsa-mir-4537 ; hsa-mir-7703 ; hsa-mir-661 ; hsa-mir-3116 ; hsa-mir-1254 ; hsa-mir-4252 ; hsa-mir-4708-5p ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-4793-3p ; hsa-mir-1976 ; hsa-mir-939-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-1273g-3p ; hsa-mir-483-3p ; hsa-mir-4787-3p
Nearest miRNA
hsa-mir-10392/Upstream/282705; hsa-let-7a-2/Downstream/31775;
Nearest TSS
ENST00000527297/Upstream/18421; ENST00000612303/Downstream/10091;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/7558, chr11-CpG: 81/Downstream/9309
Target sequence
GAATCGCTTGAGACAGAGGTTGCAGTGAGCCGAGATGCGCCACTGCACTCCTGCCTGGGCAACAGAGCAAGACTCCGTCTCAAAAAAAATAAAAAAATAAAAAAAATAAAATCACCTGGAATCAAAGCAGCAGGGACAGCCTGCGCTGGAGCCGCCAGAACAGGCAGGCGGGCAGCTCCGCAAGACCGAGCAACTCCAGGACGGGAGACGAGAACTGGCAGCTGACATGACCCTGTGACCAGGACATTCCAAAAG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate